UFC Fight Night: Luque vs. Muhammad is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 16, 2022, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States.
UFC Fight Night: Luque vs. Muhammad Main Card
| Weight Class | Fight | Method | Round | Results |
| Welterweight | Vicente Luque vs. Belal Muhammad | Decision | R5 (05:00) | Belal Muhammad def. Vicente Luque |
| Middleweight | Caio Borralho vs. Gadzhi Omargadzhiev | Decision | R3 (03:56) | Caio Borralho def. Gadzhi Omargadzhiev |
| Welterweight | Miguel Baeza vs. Andre Fialho | KO/TKO | R1 (04:39) | Andre Fialho def. Miguel Baeza |
| Women Bantamweight | Mayra Bueno Silva vs. Yanan Wu | Decision | R3 (05:00) | Mayra Bueno Silva def. Yanan Wu |
| Featherweight | Pat Sabatini vs. TJ Laramie | Decision | R3 (05:00) | Pat Sabatini def. TJ Laramie |
| Welterweight | Mounir Lazzez vs. Ange Loosa | Decision | R3 (05:00) | Mounir Lazzez def. Ange Loosa |
UFC Fight Night: Luque vs. Muhammad Preliminary Card
| Weight Class | Fight | Method | Round | Results |
| Light Heavyweight | Devin Clark vs. William Knight | KO/TKO | R3 (03:21) | Devin Clark def. William Knight |
| Women Bantamweight | Lina Lansberg vs. Pannie Kianzad | Decision | R3 (05:00) | Pannie Kianzad def. Lina Lansberg |
| Lightweight | Drakkar Klose vs. Brandon Jenkins | KO/TKO | R2 (00:33) | Drakkar Klose def. Brandon Jenkins |
| Lightweight | Rafa Garcia vs. Jesse Ronson | Submission | R2 (04:50) | Rafa Garcia def. Jesse Ronson |
| Heavyweight | Chris Barnett vs. Martin Buday | Decision | R3 (01:38) | Martin Buday def. Chris Barnett |
| Lightweight | Jordan Leavitt vs. Trey Ogden | Decision | R3 (05:00) | Jordan Leavitt def. Trey Ogden |
| Women Strawweight | Istela Nunes vs. Sam Hughes | Decision | R3 (05:00) | Sam Hughes def. Istela Nunes |
| Bantamweight | Alatengheili vs. Kevin Croom | KO/TKO | R1 (00:47) | Alatengheili def. Kevin Croom |