UFC Fight Night: Lewis vs. Daukaus is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on December 18, 2021 at UFC Apex in Las Vegas, United States.
UFC Fight Night: Lewis vs. Daukaus Main Card Results
| Weight Class | Fight | Method | Round | Results |
| Heavyweight | Derrick Lewis vs Chris Daukaus | KO (punches) | R1 (03:36) | Derrick Lewis def. Chris Daukaus |
| Welterweight | Belal Muhammad vs Stephen Thompson | Decision | R3 (05:00) | Belal Muhammad def. Stephen Thompson |
| Women’s Strawweight | Amanda Lemos vs Angela Hill | Decision (split) | R3 (05:00) | Amanda Lemos def. Angela Hill |
| Bantamweight | Ricky Simón vs Raphael Assunção | KO (punches) | R2 (02:14) | Ricky Simón def. Raphael Assunção |
| Lightweight | Mateusz Gamrot vs Carlos Diego Ferreira | TKO (submission to knee to the body) | R2 (03:26) | Mateusz Gamrot def. Carlos Diego Ferreira |
| Featherweight | Cub Swanson vs Darren Elkins | TKO (spinning wheel kick and punches) | R1 (02:12) | Cub Swanson def. Darren Elkins |
UFC Fight Night: Lewis vs. Daukaus Preliminary Card Results
| Weight Class | Fight | Method | Round | Results |
| Middleweight | Gerald Meerschaert vs Dustin Stoltzfus | Submission (rear-naked choke) | R3 (02:58) | Gerald Meerschaert def. Dustin Stoltzfus |
| Catchweight (267 lb) | Justin Tafa vs Harry Hunsucker | KO (head kick) | R1 (01:53) | Justin Tafa def. Harry Hunsucker |
| Catchweight (127.5 lb) | Melissa Gatto vs Sijara Eubanks | TKO (body kick and punches) | R1 (00:45) | Melissa Gatto def. Sijara Eubanks |
| Featherweight | Charles Jourdain vs Andre Ewell | Decision (unanimous) | R3 (05:00) | Charles Jourdain def. Andre Ewell |
| Catchweight (148.5 lb) | Raquel Pennington vs Macy Chiasson | Submission (guillotine choke) | R2 (03:07) | Raquel Pennington def. Macy Chiasson |
| Heavyweight | Donald Mayes vs Josh Parisian | TKO (elbows) | R3 (03:26) | Don’Tale Mayes def. Josh Parisian |
| Lightweight | Jordan Leavitt vs Matt Sayles | Submission (inverted triangle choke) | R2 (02:05) | Jordan Leavitt def. Matt Sayles |