UFC Fight Night: Costa vs. Vettori is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 23, 2021 at the UFC APEX, Las Vegas United States.
Main Card
| Weight Class | Fight | Method | Round | Results |
| Middleweight | Paulo Costa vs. Marvin Vettori | Decision | R5 (05:00) | Marvin Vettori def. Paulo Costa |
| Lightweight | Grant Dawson vs. Rick Glenn | Decision | R3 (05:00) | Draw |
| Women Bantamweight | Jessica-Rose Clark vs. Joselyne Edwards | Decision | R3 (05:00) | Jessica-Rose Clark def. Joselyne Edwards |
| Featherweight | Alex Caceres vs. Choi Seung-Woo | Submission | R2 (03:31) | Alex Caceres def. Choi Seung-Woo |
| Welterweight | Francisco Trinaldo vs. Dwight Grant | Decision | R3 (05:00) | Francisco Trinaldo def. Dwight Grant |
| Light Heavyweight | Nicolae Negumereanu vs. Ike Villanueva | KO/TKO | R1 (01:18) | Nicolae Negumereanu def. Ike Villanueva |
Preliminary Card
| Weight Class | Fight | Method | Round | Results |
| Middleweight | Park Jun-yong vs. Gregory Rodrigues | KO/TKO | R2 (03:13) | Gregory Rodrigues def. Park Jun-yong |
| Lightweight | Mason Jones vs. David Onama | Decision | R3 (05:00) | Mason Jones def. David Onama |
| Women Strawweight | Tabatha Ricci vs. Maria Oliveira | Decision | R3 (05:00) | Tabatha Ricci def. Maria Oliveira |
| Middleweight | Jamie Pickett vs. Laureano Staropoli | Decision | R3 (05:00) | Jamie Pickett def. Laureano Staropoli |
| Lightweight | Khama Worthy vs. Jai Herbert | KO/TKO | R1 (02:47) | Jai Herbert def. Khama Worthy |
| Flyweight | Jeff Molina vs. Daniel Lacerda | KO/TKO | R2 (00:46) | Jeff Molina def. Daniel Lacerda |
| Women Strawweight | Lívia Renata Souza vs. Randa Markos | Decision | R3 (05:00) | Randa Markos def. Lívia Renata Souza |
| Bantamweight | Jonathan Martinez vs. Zviad Lazishvili | Decision | R3 (05:00) | Jonathan Martinez def. Zviad Lazishvili |